2020

Peripheral tetrahydrobiopterin is involved in the pathogenesis of mechanical hypersensitivity in a rodent postsurgical pain model.
Arai H, Takahashi R, Sakamoto Y, Kitano T, Mashita O, Hara S, Yoshikawa S, Kawasaki K, Ichinose H.
Pain. 2020 Jun 5 doi: 10.1097/j.pain.0000000000001946.

Exposure to acrylamide decreases noradrenergic axons in rat brain
Zhang L, Hara S, Ichinose H, Nagashima D, Morita K, Sakurai T, Ichihara S, Ichihara G.
Neurotoxicology. 2020 Mar 5;78:127-133. doi: 10.1016/j.neuro.2020.03.001.

2019

Deficiency of ascorbic acid decreases the contents of tetrahydrobiopterin in the liver and the brain of ODS rats.
Naoki Takeshita, Noe Kawade, Wakana Suzuki, Satoshi Hara, Fumihiko Horio, Hiroshi Ichinose
Neurosci Lett. 2019 Nov 30. doi:10.1016/j.neulet.2019.134656

A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function.
Miramontes-Gonzalez JP, Hightower M, Zhang K, Kurosaki H, Schork AJ, Biswas N, Vaingankar S, Mahata M, Lipkowitz MS, Nievergelt CM, Baker DG, Ziegler MG, León-Jiménez D, González-Sarmiento R, Ichinose H, O'Connor DT.
Sci Rep. 2019 Mar 25;9(1):5055. doi: 10.1038/s41598-019-41504-7.

Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP.
Kurosaki H, Yamaguchi K, Man-Yoshi K, Muramatsu S, Hara S, Ichinose H.
Neurochem Int. 2019 May;125:16-24. doi: 10.1016/j.neuint.2019.02.005.

Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity.
Hara S, Fukumura S, Ichinose H.
J Biol Chem. 2019 Jan 25;294(4):1420-1427. doi: 10.1074/jbc.RA118.005280

2018

The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis.
Jin F, Li X, Deng Y, Timilshina M, Huang B, Kim DY, Chang JH, Ichinose H, Baek SH, Murakami M, Lee YJ, Chang HW.
Allergy. 2018 Dec 19. doi: 10.1111/all.13702.

Nuclear Receptor Nur77 Deficiency Alters Dendritic Cell Function.
Tel-Karthaus N, Kers-Rebel ED, Looman MW, Ichinose H, de Vries CJ, Ansems M.
Front Immunol. 2018 Aug 3;9:1797.

Human tyrosine hydroxylase in Parkinson's disease and in related disorders.
Nagatsu T, Nakashima A, Ichinose H, Kobayashi K.
J Neural Transm (Vienna). 2018 Jul 11.

Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.
Ichinose H, Inoue KI, Arakawa S, Watanabe Y, Kurosaki H, Koshiba S, Hustad E, Takada M, Aasly JO.
J Neural Transm (Vienna). 2018 Jan;125(1):45-52.

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2017

L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.
Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y.
JCI Insight. 2017 Sep 21;2(18).

The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation.
Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G, Kronke G.
J Immunol. 2017 May 15;198(10):3878-3885.

Sepiapterin reductase gene-disrupted mice suffer from hypertension with fluctuation and bradycardia.
Sumi-Ichinose C, Suganuma Y, Kano T, Ihira N, Nomura H, Ikemoto K, Hata T, Katoh S, Ichinose H, Kondo K.
Physiol Rep. 2017 Mar;5(6). pii: e13196.

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2016

Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
Ishikawa T, Imamura K, Kondo T, Koshiba Y, Hara S, Ichinose H, Furujo M, Kinoshita M, Oeda T, Takahashi J, Takahashi R, Inoue H.
Hum Mol Genet. 2016 Dec 1;25(23):5188-5197.

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Korner G, Scherer T, Adamsen D, Rebuffat A, Crabtree M, Rassi A, Scavelli R, Homma D, Ledermann B, Konrad D, Ichinose H, Wolfrum C, Horsch M, Rathkolb B, Klingenspor M, Beckers J, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Blau N, Rozman J, Thony B.
J Inherit Metab Dis. 2016 Mar;39(2):309-19.

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2015

Patrolling monocytes control tumor metastasis to the lung.
Hanna RN, Cekic C, Sag D, Tacke R, Thomas GD, Nowyhed H, Herrley E, Rasquinha N, McArdle S, Wu R, Peluso E, Metzger D, Ichinose H, Shaked I, Chodaczek G, Biswas SK, Hedrick CC.
Science 2015 Nov 20;350(6263):985-90.

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.
Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A.
J Exp Med. 2015 Sep 21;212(10):1623-40.

Dopamine or biopterin deficiency potentiates phosphorylation at 40Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system.
Kawahata I, Ohtaku S, Tomioka Y, Ichinose H, Yamakuni T.
Biochem Biophys Res Commun. 2015 Sep 11;465(1):53-8.

Redox sensor proteins for highly sensitive direct imaging of intracellular redox state.
Sugiura K, Nagai T, Nakano M, Ichinose H, Nakabayashi T, Ohta N, Hisabori T.
Biochem Biophys Res Commun. 2015 Feb 13;457(3):242-8.

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2014

Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.
Xu F, Sudo Y, Sanechika S, Yamashita J, Shimaguchi S, Honda S, Sumi-Ichinose C, Mori-Kojima M, Nakata R, Furuta T, Sakurai M, Sugimoto M, Soga T, Kondo K, Ichinose H.
FEBS Lett. 2014 Nov 3;588(21):3924-31.

A functional polymorphism of the GTP cyclohydrolase 1 gene predicts attention performance.
Yasuda Y, Hashimoto R, Ohi K, Yamamori H, Fujimoto M, Umeda-Yano S, Fujino H, Fukunaga M, Horiguchi M, Takeda M, Ichinose H.
Neurosci Lett. 2014 Apr 30;566:46-9.

Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia.
Horiguchi M, Ohi K, Hashimoto R, Hao Q, Yasuda Y, Yamamori H, Fujimoto M, Umeda-Yano S, Takeda M, Ichinose H.
Psychiatry Clin Neurosci. 2014 Jun;68(6):456-62.

A nationwide survey of Aicardi-Goutieres syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study.
Abe J, Nakamura K, Nishikomori R, Kato M, Mitsuiki N, Izawa K, Awaya T, Kawai T, Yasumi T, Toyoshima I, Hasegawa K, Ohshima Y, Hiragi T, Sasahara Y, Suzuki Y, Kikuchi M, Osaka H, Ohya T, Ninomiya S, Fujikawa S, Akasaka M, Iwata N, Kawakita A, Funatsuka M, Shintaku H, Ohara O, Ichinose H, Heike T.
Rheumatology (Oxford). 2014 Mar;53(3):448-58.

Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons.
Tokuoka H, Hatanaka T, Metzger D, Ichinose H.
Neurosci Lett. 2014 Jan 24;559:50-5.

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2013

Identification of an enhancer region for immune activation in the human GTP cyclohydrolase I gene.
Liang Y, Inagaki H, Hao Q, Sakamoto M, Ohye T, Suzuki T, Ichinose H.
Biochem Biophys Res Commun. 2013 Dec 6;442(1-2):72-8.

Birth regulates the initiation of sensory map formation through serotonin signaling.
Toda T, Homma D, Tokuoka H, Hayakawa I, Sugimoto Y, Ichinose H, Kawasaki H.
Dev Cell. 2013 Oct 14;27(1):32-46.

Dopa-responsive dystonia: functional analysis of single nucleotide substitutions within the 5' untranslated GCH1 region.
Armata IA, Balaj L, Kuster JK, Zhang X, Tsai S, Armatas AA, Multhaupt-Buell TJ, Soberman R, Breakefield XO, Ichinose H, Sharma N.
PLoS One. 2013 Oct 4;8(10):e76975.

AADC deficiency: occurring in humans, modeled in rodents.
Hwu WL, Lee NC, Chien YH, Muramatsu S, Ichinose H.
Adv Pharmacol. 2013;68:273-84.

GTP cyclohydrolase regulation: implications for brain development and function.
Ichinose H, Homma D, Sumi-Ichinose C, Nomura T, Kondo K.
Adv Pharmacol. 2013;68:23-35.

The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain.
Homma D, Katoh S, Tokuoka H, Ichinose H.
J Neurochem. 2013 Jul;126(1):70-81.

Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.
Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A.
Nat Immunol. 2013 Mar;14(3):230-7.

Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency.
Lee NC, Shieh YD, Chien YH, Tzen KY, Yu IS, Chen PW, Hu MH, Hu MK, Muramatsu S, Ichinose H, Hwu WL.
Neurobiol Dis. 2013 Apr;52:177-90.

Association of monoamine-synthesizing genes with the depression tendency and personality in chronic fatigue syndrome patients.
Fukuda S, Horiguchi M, Yamaguti K, Nakatomi Y, Kuratsune H, Ichinose H, Watanabe Y.
Life Sci. 2013 Feb 27;92(3):183-6.

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2012

GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder.
Kishi T, Ichinose H, Yoshimura R, Fukuo Y, Kitajima T, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Musso GM, Umene-Nakano W, Nakamura J, Ozaki N, Iwata N.
J Affect Disord. 2012 Dec 15;142(1-3):315-22.

The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila.
Kanao T, Sawada T, Davies SA, Ichinose H, Hasegawa K, Takahashi R, Hattori N, Imai Y.
PLoS One. 2012;7(2):e30958.

Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy.
Yagi H, Sanechika S, Ichinose H, Sumi-Ichinose C, Mizukami H, Urabe M, Ozawa K, Kume A.
Neuroreport. 2012 Jan 4;23(1):30-4.

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2011

Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.
Tokuoka H, Muramatsu S, Sumi-Ichinose C, Sakane H, Kojima M, Aso Y, Nomura T, Metzger D, Ichinose H.
J Biol Chem. 2011 Dec 16;286(50):43549-58.

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.
Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, Rudensky AY, Ichinose H, Metzger D, Chambon P, Yoshimura A.
Nat Commun. 2011;2:269.

Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T).
Koshiba S, Tokuoka H, Yokoyama T, Horiuchi E, Ichinose H, Hasegawa K.
J Neural Transm. 2011 Jun;118(6):899-903.

Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.
Homma D, Sumi-Ichinose C, Tokuoka H, Ikemoto K, Nomura T, Kondo K, Katoh S, Ichinose H.
J Biol Chem. 2011 Jan 14;286(2):1445-52.

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2010

Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca(2+) signals evoked via the N-methyl-D-aspartate (NMDA) receptor.
Fukuchi M, Fujii H, Takachi H, Ichinose H, Kuwana Y, Tabuchi A, Tsuda M.
Brain Res. 2010 Dec 17;1366:18-26.

Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals.
Sumi-Ichinose C, Ichinose H, Ikemoto K, Nomura T, Kondo K.
J Pharmacol Sci. 2010;114(1):17-24.

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2009

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.
Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Bjorklund A, Ichinose H, Perlmann T.
J Neurosci. 2009 Dec 16;29(50):15923-32.

Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells.
Kawahata I, Tokuoka H, Parvez H, Ichinose H.
J Neural Transm. 2009 Dec;116(12):1571-8.

Effects of TRK-820, a selective kappa opioid receptor agonist, on rat schizophrenia models.
Yoshikawa S, Hareyama N, Ikeda K, Kurokawa T, Nakajima M, Nakao K, Mochizuki H, Ichinose H.
Eur J Pharmacol. 2009 Mar 15;606(1-3):102-8.

H2O2 increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo.
Chavan, B., Beazley, W., Wood, J.M., Rokos, H., Ichinose, H., and Schallreuter, K.U.
J Inherit Metab Dis. 2009 Feb 32(1), 86-94.?

Immunohistochemical analyses of the postmortem human brains from patients with Parkinson's disease with anti-tyrosine hydroxylase antibodies.
Kawahata, I., Yagishita, S., Hasegawa, K., Nagatsu, I., Nagatsu, T., and Ichinose, H.
Biogenic Amines 2009 23, 1-7.

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2008

Metabolism of tetrahydrobiopterin: its relevance in monoaminergic neurons and neurological disorders.
Ichinose H, Nomura T, Sumi-Ichinose C.
Chem Rec. 2008;8(6):378-85.

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T.
Mol Brain. 2008 Sep 10;1:6.

Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia.
Sato K, Sumi-Ichinose C, Kaji R, Ikemoto K, Nomura T, Nagatsu I, Ichinose H, Ito M, Sako W, Nagahiro S, Graybiel AM, Goto S.
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12551-6

A new mutation in the GCH1 gene presents as early-onset Parkinsonism.
Momma K, Funayama M, Li Y, Ichinose H, Motoyoshi K, Hattori N, Mizuno Y, Kamakura K.
Parkinsonism Relat Disord. 2008 May 27.

A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice--as a mouse model for Parkinson's disease.
Takazawa C, Fujimoto K, Homma D, Sumi-Ichinose C, Nomura T, Ichinose H, Katoh S.
Biochem Biophys Res Commun. 2008 Mar 21;367(4):787-92.

Increased expression of tyrosine hydroxylase and anomalous neurites in catecholaminergic neurons of ATF-2 null mice.
Kojima M, Suzuki T, Maekawa T, Ishii S, Sumi-Ichinose C, Nomura T, Ichinose H.
J Neurosci Res. 2008 Feb 15;86(3):544-52.

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2007

Identification of the causative gene for Segawa's disease.
Ichinose H, Nagatsu T.
Rinsho Shinkeigaku. 2007 Nov;47(11):735-8.

Real-time bioluminescence imaging of a protein secretory pathway in living mammalian cells using Gaussia luciferase.
Suzuki T, Usuda S, Ichinose H, Inouye S.
FEBS Lett. 2007 Oct 2;581(24):4551-6.

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
Neurosci Res. 2007 Mar;57(3):446-53. Epub 2007 Jan 8.

Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4: site-specific expression of mouse Abcg4 in brain.
Koshiba S, Ito T, Shiota A, Wakabayashi K, Ueda M, Ichinose H, Ishikawa T.
J Exp Ther Oncol. 2007;6(4):321-33.

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2006

Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease.
Li XG, Okada T, Kodera M, Nara Y, Takino N, Muramatsu C, Ikeguchi K, Urano F, Ichinose H, Metzger D, Chambon P, Nakano I, Ozawa K, Muramatsu S.
Mol Ther. 2006 Jan;13(1):160-6.

Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: formation of insoluble aggregates of tyrosine hydroxylase.
Urano F, Hayashi N, Arisaka F, Kurita H, Murata S, Ichinose H.
J Biochem (Tokyo) 2006 Apr;139(4):625-35.

Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase.
Sakai K, Suzuki H, Oda H, Akaike T, Azuma Y, Murakami T, Sugi K, Ito T, Ichinose H, Koyasu S, Shirai M.
J Biol Chem. 2006 Jun 30;281(26):17736-42.

Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity.
Ogawa S, Ichinose H.
Neurosci Lett. 2006 Jul 3;401(3):261-5.

Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia.
Ohta E, Funayama M, Ichinose H, Toyoshima I, Urano F, Matsuo M, Tomoko N, Yukihiko K, Yoshino S, Yokoyama H, Shimazu H, Maeda K, Hasegawa K, Obata F.
Arch Neurol. 2006 Nov;63(11):1605-10.

A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene.
Furuya H, Murai H, Takasugi K, Ohyagi Y, Urano F, Kishi T, Ichinose H, Kira J.
Clin Neurol Neurosurg. 2006 Dec;108(8):784-6

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2005

Suppression by an h current of spontaneous Na+ action potentials in human cone and rod photoreceptors.
Kawai F, Horiguchi M, Ichinose H, Ohkuma M, Isobe R, Miyachi E.
Invest Ophthalmol Vis Sci. 2005 Jan;46(1):390-7.

A new mutation (Thr106Ile) of the GTP cyclohydrolase 1 gene associated with DYT5 dystonia (Segawa disease).
Ohta E, Toyoshima I, Funayama M, Ichinose H, Hasegawa K, Obata F.
Mov Disord. 2005 Aug;20(8):1083-4.

Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease.
Okuno T, Nakatsuji Y, Kumanogoh A, Moriya M, Ichinose H, Sumi H, Fujimura H, Kikutani H, Sakoda S.
J Neurosci Res. 2005 Sep 15;81(6):874-82.

Nerve growth factor-induced expression of the GTP cyclohydrolase I gene via Ras/MEK pathway in PC12D cells.
Ito T, Suzuki T, Ichinose H.
J Neurochem. 2005 Oct;95(2):563-9.

Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities.
Sumi-Ichinose C, Urano F, Shimomura A, Sato T, Ikemoto K, Shiraishi H, Senda T, Ichinose H, Nomura T.
J Neurochem. 2005 Nov;95(3):703-14.

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2004

Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report.
Kikuchi A, Takeda A, Fujihara K, Kimpara T, Shiga Y, Tanji H, Nagai M, Ichinose H, Urano F, Okamura N, Arai H, Itoyama Y.
Mov Disord. 2004 May;19(5):590-3.

Ras/MEK pathway is required for NGF-induced expression of tyrosine hydroxylase gene.
Suzuki T, Kurahashi H, Ichinose H.
Biochem Biophys Res Commun. 2004 Mar;5:315(2):389-96.

GTP cyclohydrolase I utilizes metal-free GTP as its substrate.
Suzuki T, Kurita H, Ichinose H.
Eur J Biochem. 2004 Jan;271:349-55

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2003

cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells.
Shiraishi H, Kato T, Atsuta K, Sumi-Ichinose C, Ohtsuki M, Itoh M, Hishida H, Tada S, Udagawa Y, Nagatsu T, Hagino Y, Ichinose H, Nomura T.
J Pharmacol Sci. 2003 Nov;93(3):265-71.

Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell.
Kim TE, Lee HS, Lee YB, Hong SH, Lee YS, Ichinose H, Kim SU, Lee MA.
Biochem Biophys Res Commun. 2003 Jun 13;305(4):1040-8.

Effects of chronic treatment with L-arginine on atherosclerosis in apoE knockout and apoE/inducible NO synthase double-knockout mice.
Chen J, Kuhlencordt P, Urano F, Ichinose H, Astern J, Huang PL.
Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):97-103.

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