2002

A highly sensitive and specific FDCD method for chirality analysis of naturally occuring pteridines.
Chen N, Ikemoto K, Sugimoto T, Murata S, Ichinose H, and Nagatsu T.
Heterocycles 2002 Jan;56:387-392

Generation of TH+ dopaminergic neurons and Pax6+ pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.
Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, Ichinose H, Haruta M, Takahashi M, Yoshikawa K, Nishikawa S, Nakatsuji N, and Sasai Y.
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1580-5.

(6R)-5,6,7,8-tetrahydro-L-monapterin from Esherichia coli, a novel natural unconjugated tetrahdropterin.
Ikemoto K, Sugimoto T, Murata S, Tazawa M, Nomura T, Ichinose H, and Nagatsu T.
Biol Chem. 2002 Feb;383(2):325-30.

Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes.
Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, and Ozawa K.
Hum Gene Ther. 2002 Feb 10;13(3):345-54.

Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease.
Wang L, Muramatsu S, Lu Y, Ikeguchi K, Fujimoto K, Okada T, Mizukami H, Hanazono Y, Kume A, Urano F, Ichinose H, Nagatsu T, Nakano I, and Ozawa K.
Gene Ther. 2002 Mar;9(6):381-9.

cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells.
Ohtsuki M, Shiraishi H, Kato T, Kuroda R, Tazawa M, Sumi-Ichinose C, Tada S, Udagawa Y, Itoh M, Hishida H, Ichinose H, Nagatsu T, Hagino Y, and Nomura T.
Life Sci. 2002 Mar 22;70(18):2187-98.

Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells.
Suzuki T, Inagaki H, Yamakuni T, Nagatsu T, Ichinose H.
Biochem Biophys Res Commun. 2002 May 10;293(3):962-8.

Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene.
Ikeno M, Inagaki H, Nagata K, Morita M, Ichinose H, Okazaki T.
Genes Cells. 2002 Oct;7(10):1021-32.

Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene.
Suzuki T, Yamakuni T, Hagiwara M, Ichinose H.
J Biol Chem. 2002 Oct 25;277(43):40768-74.

Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient.
Ihara M, Kohara N, Urano F, Ichinose H, Takao S, Nishida T, Saiki H, Kawamoto Y, Ikeda A, Takagi S, and Shibasaki H.
Neurology 2002 Oct 8;59(7):1102-4.

Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1a.
Nielsen A L, Sanchez C, Ichinose H, Cervino M, Lerouge T, Chambon P, and Losson R.
EMBO J. 2002 Nov 1;21(21):5797-806.

Localization of sepiapterin reductase in the human brain.
Ikemoto K, Suzuki T, Ichinose H, Ohye T, Nishimura A, Nishi K, Nagatsu I, and Nagatsu T.
Brain Res. 2002 Nov 8;954(2):237-46.

Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins.
Lee MA, Lee HS, Lee HS, Cho KG, Jin BK, Sohn S, Lee YS, Ichinose H, Kim SU.
Neurosci Lett. 2002 Nov 15;333(1):74-8.

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2001

A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus.
Zabetian CP, Anderson GM, Buxbaum SG, Elston RC, Ichinose H, Nagatsu T, KIm K-S, Kin C-H, Malison RT, Gelernter J, and Cubells JF.
Am J Hum Genet. 2001 Feb;68(2):515-22.

A convenient determination of chiral pteridines: Application of fluorescence detected circular dichrolism (FDCD) to the major pterin from Esherichia coli.
Sugimoto T, Ikemoto K, Murata S, Tazawa M, Nomura T, Hagino Y, Ichinose H, Nagatsu T, and Wada A.
Heterocycles 2000;54:283-290

Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains.
Mogi M, Togari A, Kondo T, Mizuno Y, Kogure O, Kuno S, Ichinose H, and Nagatsu T.
Neurosci Lett. 2001 Mar 16;300(3):179-81.

Identification of (6R)-5,6,7,8-tetrahydro-D-monopterin (=(6R)-2-amino-5,6,7,8-tetrahydro-6-[(1R,2R)-1,2,3-trihydroxypropyl]-pteridin-4(3H)-one) as the native pteridine in Tetrahymena pyriformis.
Sugimoto T, Ikemoto K, Murata S, Tazawa M, Nomura T, Hagino Y, Ichinose H, and Nagatsu T.
Helvetica Chim Acta. 2001;84:918-927

A new splicing variant for human tyrosine hydroxylase in the adrenal medulla.
Ohye T, Ichinose H, Yoshizawa T, Kanazawa I, and Nagatsu T
Neurosci Lett. 2001 Oct 26;312(3):157-60.

Catecholamines and serotonin are differently regulated by tetrahydrobiopterin: a study from 6-pyruvoyltetrahydropterin synthase knockout mice.
Sumi-Ichinose C, Urano F, Kuroda R, Ohye T, Kojima M, Tazawa M, Shiraishi H, Hagino Y, Nagatsu T, Nomura T, and Ichinose H.
J Biol Chem. 2001 Nov 2;276(44):41150-60.

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2000

Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain.
Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S, Ichinose H, and Nagatsu T.
J Neural Transm. 2000;107(3):335-41

Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromotography.
Hibiya M, Ichinose H, Ozaki N, Fujita K, Nishimoto T, Yoshikawa T, Asano Y, and Nagatsu T.
J Chromatogr B. 2000;740:35-42

Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.
Kaneko S, Hikida T, Watanabe D, Ichinose H, Nagatsu T, Kreitman RJ, Pastan I, and Nakanishi S.
Science. 2000 Jul 28;289(5479):633-7.

Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease.
Shen Y, Muramatsu S-i, Ikeguchi K, Fujimoto K-i, Fan D-S, Ogawa M, Mizukami H, Urabe M, Kume A, Nagatsu I, Urano F, Suzuki T, Ichinose H, Nagatsu T, Monahan J, Nakano I, and Ozawa K.
Hum Gene Ther. 2000 Jul 20;11(11):1509-19.

Increase in level of tumor necrosis factor-a in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506.
Mogi M, Togari A, Tanaka K-i, Ogawa N, Ichinose H, and Nagatsu T.
Neurosci Lett. 2000;289:165-168

GTP cyclohydrolase I from Tetrahymena pyriformis: cloning of cDNA and expression.
Tazawa M, Ohtsuki M, Sumi-Ichinose C, Shiraishi H, Kuroda R, Hagino Y, Nakashima S, Nozawa Y, Ichinose H, Nagatsu T, and Nomura T.
Comp Biochem Physiol B Biochem Mol Biol. 2000 Sep;127(1):65-73.

Studies on the genotype-phenotype relation in the hph-1 mouse mutant deficient in guanosine triphosphate (GTP) cyclohydrolase I activity.
Maeda T, Haeno S, Oda K, Mori D, Ichinose H, Nagatsu T, and Suzuki T.
Brain Dev. 2000 Sep;22 Suppl 1:S50-3.

Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease.
Ichinose H, Inagaki H, Suzuki T, Ohye T, and Nagatsu T.
Brain Dev. 2000 Sep;22 Suppl 1:S107-10.

Cytokines in Parkinson's disease.
Nagatsu T, Mogi M, Ichinose H, and Togari A.
J Neural Transm Suppl. 2000;(58):143-51.

Changes in cytokines and neurotrophins in Parkinson's disease.
Nagatsu T, Mogi M, Ichinose H, and Togari A.
J Neural Transm Suppl. 2000;(60):277-90.

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1999

Molecular biology of catecholamine-related enzymes in relation to Parkinson's disease.
Nagatsu T, and Ichinose H.
Cell Mol Neurobiol. 1999 Feb;19(1):57-66.

Regulation of pteridine-requiring enzymes by the cofactor tetrahydrobiopterin.
Nagatsu T, and Ichinose H.
Mol Neurobiol. 1999 Feb;19(1):79-96.

Molecular cloning of the human Nurr1 gene: Characterization of the human gene and cDNAs.
Ichinose H, Ohye T, Suzuki T, Sumi-Ichinose C, Nomura T, Hagino Y, and Nagatsu T.
Gene. 1999 Apr 16;230(2):233-9.

Neopterin and cytokines in hereditary dystonia and Parkinson's disease.
Nagatsu T, Ichinose H, Mogi M, and Togari A.
Pteridines. 1999;10:5-13

Functionally important residues tyrosine-171 and serine-158 in sepiapterin reductase.
Fujimoto K, Ichinose H, Nagatsu T, Nonaka T, Mitsui Y, and Katoh S.
Biochim Biophys Acta. 1999 May 18;1431(2):306-14.

Increase in level of tumor necrosis factor (TNF)-alpha in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic L-DOPA on the TNF-alpha induction.
Mogi M, Togari A, Tanaka K, Ogawa N, Ichinose H, and Nagatsu T.
Neurosci Lett. 1999 Jun 18;268(2):101-4.

Decrease in GTP cyclohydrolase I gene expression caused by inactivation of one allele in hereditary progressive dystonia with marked diurnal fluctuation (HPD).
Inagaki H, Ohye T, Suzuki T, Segawa M, Nomura Y, Nagatsu T, and Ichinose H.
Biochem Biophys Res Commun. 1999 Jul 14;260(3):747-51.

Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain.
Nagatsu I, Ikemoto K, Kitahama K, Nishimura A, Ichinose H, and Nagatsu T.
J Neural Transm (Vienna). 1999;106(7-8):607-17

Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease.
Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S, Ichinose H, and Nagatsu T.
Neurosci Lett. 1999 Jul 23;270(1):45-8.

Cytokines in Parkinson's disease.
Nagatsu T, Mogi M, Ichinose H, Togari A, and Riederer P.
NeuroSci News. 1999;2:88-90

Characterization of wild-type and mutants of recombinant human GTP cyclohydrolase I: Relationship to etiology of dopa-responsive dystonia.
Suzuki T, Ohye T, Inagaki H, Nagatsu T, and Ichinose H.
J Neurochem. 1999 Dec;73(6):2510-6.

Molecular genetics of Dopa-responsive dystonia.
Ichinose H, Suzuki T, Inagaki H, Ohye T, and Nagatsu T.
Biol Chem. 1999 Dec;380(12):1355-64.

Stimulus-coupled interaction of tyrosine hydroxylase with 14-3-3 proteins.
Itagaki C, Isobe T, Taoka M, Natsume T, Nomura N, Horigome T, Omata S, Ichinose H, Nagatsu T, Greene LA, and Ichimura T.
Biochemistry. 1999 Nov 23;38(47):15673-80.

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1998

Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro.
Fan D, Ogawa M, Ikeguchi K, Fujimoto K, Urabe M, Kume A, Nishizawa M, Matsushita N, Kiuchi K, Ichinose H, Nagatsu T, Kurtzman GJ, Nakano I, and Ozawa K.
Neurosci Lett. 1998 May 22;248(1):61-4.

Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis: Presence of GTP cyclohydrolase I.
Nomura T, Tazawa M, Ohtsuki M, Sumi-Ichinose C, Hagino Y, Ota A, Nakashima A, Mori K, Sugimoto T, Ueno O, Nozawa Y, Ichinose H, and Nagatsu T.
Comp Biochem Physiol B Biochem Mol Biol. 1998 Aug;120(4):753-60.

DRD2 allele frequencies and linkage disequilibria, including the - 141CIns/Del promoter polymorphism, in European-American, African- American, and Japanese subjects.
Gelernter J, Kranzler H, Cubells JF, Ichinose H, and Nagatsu T.
Genomics. 1998 Jul 1;51(1):21-6.

Genomic organization and chromosomal localization of the human sepiapterin reductase gene.
Ohye T, Hori T, Katoh S, Nagatsu T, and Ichinose H.
Biochem Biophys Res Commun. 1998 Oct 20;251(2):597-602.

Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine hydroxylase and aromatic L- amino acid decarboxylase genes using two separate adeno-associated virus vectors.
Fan DS, Ogawa M, Fujimoto KI, Ikeguchi K, Ogasawara Y, Urabe M, Nishizawa M, Nakano I, Yoshida M, Nagatsu I, Ichinose H, Nagatsu T, Kurtzman GJ, and Ozawa K.
Hum Gene Ther. 1998 Nov 20;9(17):2527-35.

[Autosomal-dominant DOPA-responsive dystonia, caused by mutations in the GTP-cyclohydrolase I gene].
Nagatsu T, and Ichinose H.
Vopr Med Khim. 1998 May-Jun;44(3):225-8. [Russian]

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